Syllabus
The lectures take place each Wednesday and Friday at The Dept. of Stomatology Lecture Hall, Kateřinská 32, Praha 2,3rd. floor: 1 3rd October 10:45-12:15 Prof. V.Kožich Introduction to biochemical genetics 2 5th October 10:45-12:15 Prof.
V.Kožich Hereditary disorders of amino-acid metabolism 3 10th October 10:45-12:15 Dr. M.Hřebíček Disorders of mitochondrial metabolism 4 12th October 10:45-12:15 Dr.
M.Hřebíček Hereditary disorders of metabolism and biogenesis of lysosomes and peroxisomes 5 17th October 10:45-12:15 Dr. M.Hřebíček Disorders of purine and pyrimidine metabolism and porphyrias; pathobiochemistry of fasting 6 19th October 10:45-12:15 Dr.M.Hřebíček Hereditary disorders of saccharide metabolism and protein glycosylation 7 24th October 10:45-12:15 Prof.
V.Kožich Diagnosis and therapy of monogenic disorders of metabolism 8 26th October 10:45-12:15 Doc. J.Křemen Mechanisms of tumour disease formation (physical, chemical and viral carcinogenesis) 9 31st.
October 10:45-12:15 Doc. Z.
Kleibl Pathobiochemistry of tumorigenesis (pathobiochemistry of malignant transformation) 10 2.nd November 10:45-12:15 Dr. M.Zikán Principles of cancer progression (regulation of angiogenesis, formation of metastases) 11 7th November 10:45-12:15 Prof.
A. Šedo Signal transduction elements as therapeutic targets 12 9th November 10:45-12:15 Doc. P.Pohlreich DNA-based diagnostics in oncology 13 14th November 10:45-12:15 Dr M.Matějů Biochemical principles of anticancer treatment 14 16th November 10:45-12:15 Dr M.Matějů Tumour markers 15 21th November 10:45-12:15 Dr.
M.Vejražka Disorders of acid-base balance 16 23th November 10:45-12:15 Dr. J.
Pláteník Reactive oxygen and nitrogen species in the body, the antioxidant defence 17 28th November 10:45-12:15 Dr. J.
Pláteník Ageing 18 30th November 10:45-12:15 Dr. M.Vejražka Atherosclerosis 19 5th December 10:45-12:15 Prof.
J. Jonák Disorders of protein folding and their clinical consequences.
Prions 21 7th December 10:45-12:15 Dr. J.Krtil Non-enzymatic glycations, insulinoresistance, metabolic syndrome 22 19th December 10:45-12:15 Dr.
J. Pláteník Death of heart and neuronal cell: ischemia/reperfusion, excitotoxicity and neurodegeneration
Annotation
Pathobiochemistry for 3rd year General Medicine students, winter term 2012/2013
The course is a series of lectures on metabolic basis of both hereditary and acquired diseases with emphasis on general pathogenetic mechanisms, rather than specific diseases. In addition, some general processes such as inflammation and allergy have been omitted on purpose, because they are taught later in specialized courses ( e.g. immunology) in much more detail than would have been possible in the limited number of lectures available for pathobiochemistry. Three areas of biochemical pathogenetic mechanisms form the backbone of the course: 1) hereditary metabolic disorders, 2) disorders of cell signaling (cancer in particular), and 3) disorders of the inner environment and limits of its maintenance (degenerative diseases, ischemia, and ageing). The lectures are given by teachers from The Institute of Inherited Metabolic Disorders, the Institute of Biochemistry and Experimental Oncology, and the Institute of Medical Biochemistry. This academic year (2012/2013) the course is organised by the The Institute of Inherited Metabolic Disorders.
The lectures are held according to the schedule (see "Syllabus") in the Lecture Hall of the Department of Stomatology, Kateřinská 32, the third floor, every Wednesday and Friday from 10.45 to 12.15. The first lecture will take place on Wednesday, 3rd. October, 2012 ("Introduction to biochemical genetics").
The lectures are non-mandatory and attendance is not taken. However, detailed knowledge of topics presented at the lectures will be required at the exam; therefore attendance at the lectures is highly recommended.
The subject ends with a credit and oral examination. The credit will be issued by the examiner at the oral exam without any specific formal requirements. Further information concerning the oral examination, including the new exam questions, and recommended study literature will be announced in the near future.
If you have any questions or comments, please contact
Martin Hřebíček, M.D., PhD. (martin.hrebicek@lf1.cuni.cz, tel. 2 2496 7208).