Syllabus
* Seminars
Structure of nucleic acids. Biosynthesis of nucleic acids.
Transcription and translation.
Blood plasma proteins and their significance. The acute phase proteins. Immunoglobulins.
Immunochemical techniques and their usage in clinical chemistry.
Biochemistry of inflammation.
Methods of molecular biology.
Essentials of cell signaling and its disorders.
Molecular biology and pathobiochemistry of tumor growth.
Saliva: origin, composition, function.
Pathobiochemistry of bones and connective tissues.
Pathobiochemistry of oral cavity. Dental plaque and dental decay.
Reactive oxygen and nitrogen species. Phagocyte weapons.
Antioxidant defence. Dietary antioxidants.
Disorders of porphyrin metabolism. Icterus.
Biochemistry and pathobiochemistry of the liver. Significance of liver in metabolism.
Disorders of hemocoagulation and techniques used in their laboratory investigation.
Influence of the oral cavity environment on various dental materials.
Methods of biochemical investigation of diabetes mellitus.
Disorders of lipid metabolism. Atherosclerosis.
Methods of biochemical investigation of disorders of lipid metabolism.
Laboratory examination of liver function. Markers of liver damage.
Disorders of nutrition. Obesity, starvation, malnutrition, deficiency of vitamins and minerals.
Importance of correct nutrition for prevention of tooth decay.
Composition of body fluids and its most common disorders.
Disorders of acid-base balance.
Biochemistry and pathobiochemistry of neurotransmitters.
Annotation
Biochemistry and pathobiochemistry for dentists will be concentrated on the fundamentals of metabolism related to the most important and most frequent diseases which may be encountered by the dentist (e.g. hemocoagulation disturbances, diabetes etc.). In detail will be discussed especially the digestion processes, defence against infection (inflammation) and metabolism of connective and hard tissues (bone and tooth).
The metabolism of calcium and its disturbances will be especially stressed. The biochemistry and pathobiochemistry of oral cavity (salive, dental plaque) will be stressed too.