Sylabus
* Lectures
Biology and genetics-introduction. Mendelian inheritance in man.
Genetics of Prokaryotes an Eukaryotes-comparison.
Cell cycle and its regulation.
Molecular genetics.
Oncogenetics.
Medical genetics.
* Practical training
Introduction. Mono and dihybridism, phenotypic ratios. Genetics of ABO, MN and Rh systems.
Genealogy, pedigree chart, types of inheritance in pedigrees, examples of monogenic disorders in men
Mitosis, human karyotype, cytogenetic analysis.
Meiotic division, chromosome segregation, non disjunction, virtual microscopy.
Numeric and structural chromosomal aberrations-syndromes.
Gene linkage, polygenic inheritance.
Population genetics, CHW formula, small population, genetic drift.
Molecular genetics I.
Molecular genetics II. Examples of DNA diagnostics.
Immunogenetics, transplantation principles,genetics of HLA and Rh systems.
Ontogenesis, examples from genetics of congenital defects, teratogenesis.
Examples of familial tumors, molecular genetics of oncogenes and tumor suppressor genes.
Principles of genetic consultation, risk assessment, indications of preventive methods.
Anotace
Předmět je zaměřen na zvládnutí vybraných základních biologických a genetických principů s akcentací vědomostí a praktických dovedností v oboru stomatologie.