Sylabus
* Lectures
Introduction, Genetics and Genomics in Medicine
Genetic aspects of mitosis, meiosis, regulation, disturbances
Structure and function of eukaryotic chromosomes, human karyotype, cytogenetic techniques
Numerical and structural chromosomal aberrations, etiology and phenotyped
Cell cycle regulation
Genealogy, traits with Mendelian mode of inheritance in pedigrees
Nonmendelian phenomena in medical genetics
Genetic linkage, its evaluation, importance in medicine
Gene interactions - changes in segregation ratios
Multifactorial inheritance, heritability
Biology and genetics of viruses, prokaryotes and eukaryotes
Ecogenetics, Pharmacogenetics, Nutrigenetics
* Practical exercises
Genetics in medicine
Mitosis
Meiosis
Numerical chromosomal aberrations
Structural chromosomal aberrations
Clinical cytogenetics
Monohybridism, dihybridism
Types of inheritance in the pedigree, examples of monogenic traits in human
Genetic linkage and its assessment in experiment and genealogy
Polygenic and multifactorial inheritance, risk assessment, trait examples
Genetic interactions
Formal genetics and cytogenetics in practice
Anotace
Biologie prokaryotní a eukaryotní buňky. Mitóza, meióza, regulace.
Mendelovská dědičnost. Multifaktoriální dědičnost.
Genetická analýza. Genová vazba.
Genealogie. Chromozómy a chromozómové aberace.