Syllabus
* Lectures:
What is pharmacology?
The scope of Pharmacology: goals, developmentof new drugs.
Pharmacokinetics I - basic principles, absorption and distribution of drugs.
Prescriptions I - (Brand name drugs), AISLP (automated information system for pharmaceutical preparations).
Pharmacokinetics II - drug elimination and clinical significance. Pharmacodynamics I - mechanisms of drug action.
Pharmacodynamics II - quantitative aspects of drug action; receptor-ligand system. Side effects of drugs; principles of gene therapy.
Drugs affecting autonomic nervous system, general principles; Sympathomimetics; Sympatholytics.
Drugs affecting autonomic nervous system, parasympathomimetics; parasympatholytics; peripheral skeletal muscle relaxants.
Local anesthetics. Introduction to drugs acting on CNS.
General anesthetics, preanaesthetic medication. Psychopharmacology; classification of main groups; neuroleptics.
Antidepressants, antimanics, psychostimulants.Nootropic and cognitive drugs, possible pharmacological intervention in neurodegenerative diseases.
Pharmacology of pain; opioid analgesics. Nonsteroidal anti-inflammatory drugs.
Hypnotics and anxiolytics. Antiepileptics.
Nitric oxide, donors and inhibitors and clinical implications. Drugs used in angina pectoris.
Diuretics. Drugs used in heart failure.
Antiarrhytmics. Drugs acting on the coagulation, platelet adhesion and fibrinolysis. Drug used in anemias; hematopoietic growth factors.
Drugs used in GIT diseases. Drugs used for treatment respiratory diseases.
Hormones as drugs, an overview.
* Seminars:
Basic principles of drug prescription. Demonstration of pharmaceutical formulations and applications.
Prescriptions II - compounded prescriptions prepared by the pharmacist ("magisterial prescriptions"). Possible guided tour to the teaching hospital pharmacy.
Clinical implications of pharmacokinetic analyses, computer simulations. Possible guided tour to the teaching hospital pharmacy.
Molecular mechanism of drug action - computer simulations, TEST on prescription writing.
Biotransformation of drugs - significance of enzyme induction and inhibition; computer simulations. Laboratory demonstration.
Metabolism of drugs - pharmacogenetics; computer simulations. TEST on pharmacokinetics. Laboratory demonstration.
Drug interactions, drug poisoning. Laboratory demonstration.
Antiparkinsonics; computer simulations. TEST on pharmacodynamics.
H1 and H2 antihistamines - therapeutic uses of autacoids.
Ethanol and other drugs of abuse; drug dependence, computer simulation. Student´s seminar on a given topic
Neuroleptics (pharmacotherapy of schizophrenia - computer simulation. Students´seminar on a given topic)
Pharmacology of bronchial asthma (Computer simulation). TEST on ANS.
Corticosteroids as drugs and adrenocortical antagonists.
Annotation
Pharmacology is a dynamically developing field in which the knowledge of physiology, biochemistry and molecular biology is closely intertwined. It is also a field reflecting the clinical aspects of the disease.
Although the number of authorized drugs increases every year, it is also necessary to be aware of the complicated path that a potentially effective newly discovered drug substance must go before it can be evaluated in clinical trials and reach the patient. Even then, however, her life cycle does not end.
Even after its introduction into routine clinical practice, its safety is constantly monitored and in the event of the discovery of another substance with a better efficacy-safety profile, it is completely replaced. There are not many active substances that are commonly used for several decades.