Sylabus
Lectures (L):
1. Physiology, pathology and pharmacology of trace elements (iron, copper and zinc)
2. Experimental determination of metal chelation, and metal based anti- or prooxidant properties
3. Physiology of blood coagulation and its testing
4. Cardiac toxicity
5. Intracellular receptors
6. Platelets, their structure, receptors, pathways and experimental results
7. Experimental testing of the effects of compounds on vascular smooth muscles Practical lectures (PL):
1. Basic laboratory skills (weighting, pipetting, preparation of a calibration curve) – Mandatory
2. Screening of metal chelation activity
3. Screening of anticoagulant activity
4. Use of cell culture models for the study of toxic effects of drugs
5. Drug effects on intracellular receptors
6. Testing of potentially novel drugs at the platelet aggregation level
7. Testing of the effect of potentially novel drugs on the level of vascular smooth muscles
Anotace
The purpose of this subject is to provide a complete background in the area of experimental pharmacodynamics. The students will be theoretically and practically trained in the basic principles of pharmacodynamic experimentation including data elaboration and statistical analysis.
The subject is taught fully and only in English.
Conditions:
• This subject is an elective subject in the summer term of 4th year of the study. Is it possible to register the subject only after passing Pharmacology II and Pharmaceutical Chemistry II.
• Exam is oral in English, credits will be awarded based on at least 4 from 7 attendances on practical classes (all students must attend practical class No.1, and choose 3 additional practical classes)
• The student will obtain 3 credits after successfully completing the subject. Content: The subject is composed from 7 practical classes (4 hours each, 28 in total) and 7 lectures (2 hours each, 14 hours in total) which will precede and match with the topics of the practical classes. Maximal capacity: 16 students (4 groups of 4 students)