Annotation
Apart from mechanical, microbiological and stability properties, dosage forms necessary have provide also their biopharmaceutical characteristics. The output of these biopharmaceutical properties includes the achievement of the optimal blood level of active ingredients.
Therefore, the subject is concerned with deep knowledge of both the pharmacokinetic (RADME system) and the physical-chemical principles of processes at biological membranes, the influence of technological and formulation factors as well as the properties of excipients and/or API such as e.g. the polymorphism, particle size, specific surface on the biopharmaceutical characteristics of dosage forms. The attention is paid to methods of dosage forms evaluation including the mechanisms of bioavailability influencing and the evaluation of pharmaceutical bioequivalence.