Syllabus
Topics
A/ To define clinical pharmacokinetics constant and their changes by different pathological stages and how to use them for individualization of pharmacotherapy; and how to measure them in clinical conditions: 1/ Total and organ clearance 2/ Volume of distribution 3/ Plasma half-life and half-life of elimination phase 4/ Absorbtion and bioavalabilty; cmax and cmin after first dose and in steady state
The method of judgement of 5/ Loading and maintained dose and where it is necessary to use leading dose – examples 6/ Cmax, cmin and intermittent dosage scheme by chronic use of medicine 7/ Time of duration of medicines in the body and time to reach steady state 8/ Pharmacodynamics/pharmacokinetic principles and their use in clinic setting + problems of misinterpretation 9/ Calculation of speed of infusion and their clinical use in long term therapy and by individual loading dose and monitoring of medication adherence by plasma concentration measurement
B/ Changes of pharmacokinetics, monitoring of pharmacokinetic changes and methods of individualization of pharmacotherapy by 10/ elderly and children 11 – 14/ suffering with 11/ Kidney failure 12/ Liver failure 13/ Cardiac failure 14/ Changes of genotype or phenotype 15/ Pharmacokinetic drug/drug interactions, their monitoring and way of risk minimization
C/ Therapeutic drug monitoring 16/ TDM – best practice and main barriers for good individualization of pharmacotherapy and monitoring and cost benefit 17/ TDM by antibiotics 18/ TDM of cytostatic and immunosuppressive agents 19/ TDM of antiepileptic’s 20/ TDM of psychiatric agents
The student will show by exam beside theory , skills to work with population data from Micromedex, UpToDate and SPC and by solving of one case with help of software MW Pharm
Annotation
The topics are related to the application of pharmacokinetic parameters and Therapeutic Drug Monitoring (TDM) in the concept of rational use of drugs. It shows the possibility of acquiring population and individual pharmacokinetic parameters and their significance for the dosage schemes and compliance.