Kyslík a antioxidační mechanismy
Toxické formy kyslíku, mechanismus vzniku a účinku. Obranné systémy parazitů.
Energetický metabolismus anaerobů
Zvláštnosti metabolismu anaerobních parazitů. Trichomonády, Entamoeba, Giardia. Mechanismus účinku chemoterapeutik.
Energetický metabolismus kinetoplastid
Zvláštnosti metabolismu kinetoplastid. Glykosom, funkce mitochondrie. Trypanosomy, leishmanie. Mechanismus účinku chemoterapeutik.
Některé aspekty biochemie apikomplex
Energetický metabolismus, mitochondrie, apikoplast a trávicí vakuola plasmodií. Modifikace erytrocytu. Mechanismus účinku chemoterapeutik.
Některé aspekty biochemie helmintů
Zvláštnosti biochemie helmintů, energetický metabolismus, anaerobní mitochondrie. Ascaris, Fasciola, schistosomy.
Polyaminy
Struktura, funkce a metabolismus polyaminů parazitů.
Proteázy
Klasifikace proteáz, význam pro parazity. Typické proteázy parazitů.
Biochemistry of Parasites - syllabus
\r\n
Oxygen and antioxidant mechanisms
Reactive oxygen species, mechanisms of their formation and toxicity. Antioxidant defense of parasites.
Energy metabolism of anaerobes
Specific aspects of metabolism of anaerobic parasites. Trichomonads, Entamoeba, Giardia. Modes of action of chemotherapeutics.
Energy metabolism of Kinetoplastida
Specific aspects of metabolism of kinetoplastid parasites. Glycosome, function of mitochondria. Trypanosomes, Leishmania. Modes of action of chemotherapeutics.
Some aspects of Apicomplexan metabolism
Energy metabolism, mitochondria, apicoplast and food vacuole of Plasmodia. Erythrocyte modification. Modes of action of chemotherapeutics.
Some aspects of helminth metabolism
Specific aspects of metabolism of parasitic helminths. Energy metabolism, anaerobic mitochondrion. Ascaris, Fasciola, Schistosomes.
Polyamines
Structure, function and metabolism of polyamines in parasites.
Proteases
Classification of proteases, their role in parasites. Typical proteases of parasites.
Biochemistry of Parasites - syllabus
Oxygen and antioxidant mechanisms Reactive oxygen species, mechanisms of their formation and toxicity. Antioxidant defense of parasites. Energy metabolism of anaerobes Specific aspects of metabolism of anaerobic parasites. Trichomonads, Entamoeba, Giardia. Modes of action of chemotherapeutics. Energy metabolism of Kinetoplastida Specific aspects of metabolism of kinetoplastid parasites. Glycosome, function of mitochondria. Trypanosomes, Leishmania. Modes of action of chemotherapeutics. Some aspects of Apicomplexan metabolism Energy metabolism, mitochondria, apicoplast and food vacuole of Plasmodia. Erythrocyte modification. Modes of action of chemotherapeutics. Some aspects of helminth metabolism Specific aspects of metabolism of parasitic helminths. Energy metabolism, anaerobic mitochondrion. Ascaris, Fasciola, Schistosomes. Polyamines Structure, function and metabolism of polyamines in parasites. Proteases Classification of proteases, their role in parasites. Typical proteases of parasites.
The course focuses on important features of metabolism of major protozoal and helminth parasites. It deals with carbohydrate catabolism, polyamine and lipid metabolism, purine and pyrimidine metabolism, proteases and antioxidant defenses of parasites. Where appropriate, the course stresses the differences in metabolism between parasites and their mammalian hosts and explains how these differences were exploited in antiparasitic drug design
J.J. Marr, M. Muller, Biochemistry and Molecular biology of Parasites. Academic Press Inc., San Diego, London, 1995