PROGRAM OF THE COURSE

All lectures will be held in English by selected scientists from Czechia and abroad.

The course is composed of 43 lectures organized into the following thematic blocks:

DNA/cell nucleus: nuclear microstructure-function relationship, organization and function of the 3D genome, retroviruses and mobile elements, human genome structure and evolution, telomere biology.

RNA: organization and regulation of RNA polymerase II transcription, transcription and splicing regulation, tRNA metabolism, RNA editing, small RNA pathways.

Proteins: eukaryotic protein synthesi, structural biology tools, proteomics and proteomes, protein structure predictions, protein turnover.

Cell biology and signaling: ensemble dynamics of cytoskeletal proteins, microtubules and signal transduction, biology of flagella and cilia, cytoskeletal organization and tissue mechanics, cellular iron metabolism and oxygen radicals, biology of mitochondria, lipid biology.

Developmental biology: oocyte-to-zygote transision, induced pluripotent stem cells and organoids, zebrafish as a model system in developmental biology, comparative developmental biology, hematopoiesis.

Biomedicine – genomics: rare genetic variants in Mendelian complex diseases, high-throughput seqencing methods, epigenetic disorders and therapy, guided nucleases and their use in biomedicine.

Biomedicine – cancer biology: chromosomal alterations in cancer cells, ADP-ribose metabolism and DNA breaks in human disease, DNA replication, cancer metabolism, DNA damage response and cellular checkpoints in cancer.

Biomedicine – hematology & immunology: Epigenetic regulation in leukemia predisposition and myelodysplastic syndromes, metabolic vulnerabilities in leukemia, gene editing in bone marrow failure synfromes, immune cell signaling, current concepts in tumor immunology and immunotherapy.

Career development workshop: career paths in science-research and alternatives, life with science, scientific communication. research ethics and scientific misconduct.

At the end of the course participants receive a credit into “indexes“ and SIS.