1. Hydrophilic and hydrophobic xenobiotics

2. The fate of xenobiotics in organisms (entry to organisms, transport in organisms and into the cells, biotransformation, elimination, excretion)

3. Pharmacokinetics of xenobiotics

4. The effects of xenobiotics on metabolic processes (target metabolic pathways for individual xenobiotics - e.g. heavy metals, air and industrial pollutants, car exhausts, drugs, potential toxicants, mutagens, teratogens, carcinogens

5. Metabolic conversion of xenobiotics in organisms (activation, detoxication)

6. Two phases of biotransformation (derivatization, conjugation). Elimination of xenobiotics from cells

7. Types of reactions involved in both phases of biotransformation (oxidation, reduction, conjugation reactions, hydrolysis]

8. Enzymes participating in xenobiotics biotransformation (the system of microsomal mixed function oxidases/oxygenases containing cytochromes P450 as terminal oxidases, microsomal monooxygenases containing flavine, peroxidases, reductases, amidases, esterases, epoxid hydrolase, UDP-glucuronoside transferase, sulphotransferases, glutathione-S-transferases, aminoacyltransferases)

9. Regulation of xenobiotic biotrasformation

References
Voet D., Voet J.: Biochemistry, John Wiley & Sons, Inc. 1990.
Jindra A., Kovács P., Pšenák M., Šípal Z.: Biochémia. Molekularobiologické a farmaceutické aspekty Osveta. 1985.