Biochemistry of Parasites - syllabus

Oxygen and antioxidant mechanisms
Reactive oxygen species, mechanisms of their formation and toxicity. Antioxidant defense of parasites.

Energy metabolism of anaerobes
Specific aspects of metabolism of anaerobic parasites. Trichomonads, Entamoeba, Giardia. Modes of action of chemotherapeutics.

Energy metabolism of Kinetoplastida
Specific aspects of metabolism of kinetoplastid parasites. Glycosome, function of mitochondria. Trypanosomes, Leishmania. Modes of action of chemotherapeutics.

Some aspects of Apicomplexan metabolism
Energy metabolism, mitochondria, apicoplast and food vacuole of Plasmodia. Erythrocyte modification. Modes of action of chemotherapeutics.

Some aspects of helminth metabolism
Specific aspects of metabolism of parasitic helminths. Energy metabolism, anaerobic mitochondrion. Ascaris, Fasciola, Schistosomes.

Polyamines
Structure, function and metabolism of polyamines in parasites.

Proteases
Classification of proteases, their role in parasites. Typical proteases of parasites.