Teachers

Prof. Stanislav Micuda, M.D., Ph.D.
Assoc. Prof. Dr. Martin Sterba, Ph.D.
Assoc. Prof. Jaroslav Chladek, M.Sc., Ph.D.
Jolana Schreiberová, M.D., Ph.D.
PharmDr. Olga Lenčová, Ph.D.

Lectures

The lectures will take place face-to-face in MS Teams in the form of "live" transmission, or an academic staff member will prepare a Powerpoint presentation with inserted voice comments. Video of the lecture will then be uploaded to our Moodle page. The presenting teacher will be online to answer questions during class time or will be available to students for consultations or questions about the lecture in another adequate way. The method of presentation will be up to the individual lecturer. The students will be informed about this in advance. The recorded lectures will be permanently available on the corresponding Moodle page.

1. Basic principles of pharmacology. Pharmacodynamics.
2. Pharmacokinetics. Pharmacokinetic parameters.
3. Adverse and toxic effects. Drug interactions.
4. Cholinergic transmission: cholinergic agonists and antagonists.
5. Noradrenergic transmission: adrenergic agonists and antagonists.
6. Opioid analgesics.

Practical courses & seminars

1. Basic principles of pharmacology. Pharmacodynamics.
1.1. Nature of drug targets, receptors and their types.
1.2. Well-established second messengers.
1.3. Dose-response curve.
1.4. Potency and efficacy.
1.5. Agonists and antagonists.
1.6. Up and down regulations.
1.7. Variation in drug responsiveness.
1.8. Practical demonstrations: PC simulation - Isolated ileum stimulation. The demonstration will be performed by the lecturer.
1.9. Analysis of cases studies.
1.10. Test
2. Pharmacokinetics of the drugs.
2.1. Main mechanisms determining pharmacokinetics of a drug (physico-chemical properties, permeation through biomembranes, binding).
2.2. Absorption, distribution, metabolism, excretion (ADME).
2.3. Pharmacokinetic parameters, pharmacogenetics, bioavailability, bioequivalence.
2.4. Practical demonstrations: PC simulation using the PkSims software. The demonstration will be performed by the lecturer.
2.5. Analysis of cases studies.
2.6. Test
3. Adverse and toxic effects of drugs. Drug interactions. Drug development.
3.1. The seminar on: the above given topics, drug information and its sources.
3.2. Practical demonstrations: SPC (Summary of Product Characteristics), AISLP (Electronic version of the Czech Drug Formulary). The demonstration will be performed by the lecturer.
3.3. Analysis of cases studies.
3.4. Test
4. Drugs affecting cholinergic transmission: cholinergic agonists & antagonists - seminar.
4.1. Practical demonstrations: PC simulation - Cardio heart rate and blood pressure (in vivo). The demonstration will be performed by the lecturer.
4.2. Analysis of cases studies.
4.3. Test
5. Drugs affecting adrenergic transmission: adrenergic agonists & antagonists - seminar.
5.1. Practical demonstrations: PC simulation - Cardio heart rate and blood pressure (in vivo). The demonstration will be performed by the lecturer.
5.2. Analysis of cases studies.
5.3. Test
6. Control of pain - seminar.
6.1. Basic and clinical pharmacology of analgesics, both opioid and non-opioid (including NSAIDs!).
6.2. Analysis of cases studies.
6.3. Test
7. Neuroleptic, antidepressant agents, anxiolytics - microlesson and seminar.
7.1. The seminar on: Basic and clinical pharmacology of drugs used in psychotic, affective and anxiety disorders.
7.2. Video presentation: Extrapyramidal syndrome due to neuroleptics.
7.3. Analysis of cases studies.
7.4. Test
8. Hypno-sedatives, antiparkinsonics and antiepileptics - microlesson and seminar.
8.1. The seminar on: Basic and clinical pharmacology of hypno-sedative, antiparkinsonic and antiepileptic drugs.
8.2. Practical demonstrations: Therapeutic drug monitoring (TDM) in antiepileptic therapy.
8.3. Analysis of cases studies.
8.4. Test
9. Skeletal muscle relaxants. General and local anesthetics.
9.1. The seminar on: Local anesthetics and skeletal muscle relaxants.
9.2. Microlesson: General anesthetics.
9.3. Analysis of cases studies.
9.4. Test.
9.5. The Credit.

Notes

Students are supposed to be theoretically prepared on each practical lesson/seminar.
Consultations with any teacher of the Department of Pharmacology are possible by prior arrangement.