Lectures

Lecturer: Doc. RNDr. Věra Králová, Ph.D.

Human chromosomes, epigenetic mehanisms, chromosome abnormalities
Mendel´s laws, Morgan´s laws, gene linkage
Single-gene inheritance
Mitochondrial inheritance
Inheritance of quantitative traits, multifactorial inheritance, heritability of traits
Immunogenetics
Pharmacogenetics
Molecular genetics methods
Genomics
Recombinant DNA technologies, gene manipulations
Prevention and treatment of genetic diseases
Introduction into the genetics of tumors

Practical courses

Lecturer: Prof. Dr. Emil Rudolf, Ph.D.

Practical courses

Meiosis and gene linkage
Meiosis in gene linkage analysis (workshop I)
Meiosis in cells of locust
Cytogenetics, cytogenetic diagnostic methods
Outline and principles of cytogenetic methodology
Karyotype of human cells
Sex chromatin in leukocyte cells
Karyotype
Preparation of karyotype from human cells cultivated in vitro
Monogenic inheritance (workshop II)
Pedigree analysis, symbols and rules in select human monogenic traits (physiological and pathological)
Examples of mechanisms of inheritance and expression of monogenic traits deviating from Mendel´s rules
Basic molecular biology techniques I
Isolation of DNA from human cells (+ e-learning)Testing genotoxicity (mutagenity) and carcinogenity
First progress test (topics 1-4)
Molecular biology methods in medical diagnostics (workshop III)
Processing and analysis of isolated nucleic acids
Examples of diagnostic use of molecular methods
Biological typing in man (workshop IV)
Use of molecular methods for identification of people – interactive workshop
Polygenic and multifactorial inheritance (workshop V)
Examples of traits ad their inheritance – interactive workshop
Second progress test (topics 5-7)
Tumor biology
Select features of malignant cells
Sporadic, familial and hereditary tumors – occurrence, differences
Population genetics (workshop VI)
Introductory concepts
Third progress test (topics 5-7)
Credit