Pathological physiology I: Syllabus of the subject - General medicine

Individual topics can be moved between the subjects pathological physiology I and pathological physiology II.

General pathophysiology I

Introduction to the subject, basic terms, disease and its course

Etiological factors

Classification of etiological and risk factors, particular intrinsic and extrinsic etiological factors

Pathophysiology of wound healing

Developmental disorders

Causes and mechanisms of developmental disorders, diseases linked to a certain age

Gametopathy, blastopathy, embryopathy, fetopathy, perinatal damage

Growth disorders

Aging, terminal states, death of an individual, cell death

Pathophysiology of immunity

Immunodeficiency, allergy, autoimmune diseases, inflammation, transplantation

Pathophysiology of thermoregulation, fever

Pathophysiology of tumors

Special pathophysiology I

Pathophysiology of the lymphatic system

Pathophysiology of the blood

Changes of blood volume and composition

Disorders of erythrocytes, anemia, polycythemia, polyglobulia, hemolysis

Pathophysiology of leukocytes – changes of number, disorders of function, leukemias

Bleeding, hemorrhagic diathesis, thrombotic states

Pathophysiology of the cardiovascular system

Inborn and acquired heart defects

Disturbances of peripheral blood circulation, atherosclerosis, endothelial dysfunction

Ischemic heart disease, arrhythmias, arterial hypertension, thromboembolic disease

Cardiac insufficiency and failure, circulatory shock

Heart hypertrophy and dilatation, cardiomyopathy, heart inflammations

Multiorgan dysfunction and multiorgan failure

Pathophysiology of the endocrine system

General causes of diseases of the endocrine glands, mechanisms of endocrine disorders

Pathophysiology of individual endocrine structures and hormones

Pathophysiology of the reproductive system

Pathophysiology of the bones

Pathophysiology of the muscles

Manifestations of diseases of the skeletal muscles and their innervation

Myopathies, muscular dystrophias, myositis, rhabdomyolysis, crush syndrome, compartment syndrome, malignant hyperthermia

Acid-base balance and its disorders

Pathophysiology of body fluids

Pathophysiology of mineral metabolism

Pathophysiology of the gastrointestinal tract

Pathophysiology of the oral cavity, esophagus, stomach, gut, exocrine pancreas

Dysphagia, nausea, vomiting, dyspepsia, constipation, diarrhea, gastrointestinal tract bleeding

Practical knowledge and skills I

Principles of science, statistics, injection technique, anesthesia, pathophysiological aspects of wound treatment, use of electricity in medicine, electrocardiography, blood pressure measurement, examination of hemorrhagic diatheses

Detailed syllabus for pathological physiolopgy I and subsequent subject pathological physiology II:

http://patofyziologie.lfp.cuni.cz/