Lectures

Identification of drugs on the basis of physical constants (melting temperature, distillation range, density, refractive index, optical rotation)
Use of physico-chemical methods for identification of drugs (spectral, separation and electrochemical methods)
Identification of drugs using chemical reactions
Group and selective reactions of individual structural types of drugs of important pharmacotherapeutical groups.
Pharmacopoeial detection of impurities using chemical reactions and physico-chemical methods
Stability of drugs, decomposition processes, factors influencing stability
Stress testing, accelerated and long-term stability testing, calculation of kinetic characteristics of decomposition reactions
Knowledge of chemism of decomposing reactions as a prerequisite for stabilization interventions

Volumetric methods used in pharmaceutical analysis
Acid-base titrations of drugs (acidimetry, alkalimetry in aqueous and non-aqueous medium)
Redox titrations of drugs (iodometry, bromatometry, permanganometry, cerimetry)
Complexometric titrations (chlatometry)
Drug assay using precipitation titrations
Spectrophotometric determination of drugs
Polarimetric determination of drugs
Determination of drugs using electroanalytical methods
Determination of drugs using chromatographic (HPLC, GC) and electrophoretic methods
Determination of drugs in biological material
Analysis of chiral drugs (purity, assay)
Development and validation of control-analytical method

Seminars & Practical training

Control-analytical evaluation of drugs according to the Pharmacopoeia
Identification of drugs using physico-chemical constants, chemical reactions, physico-chemical methods
Purity testing of drugs (chemical proofs of impurities, identification of impurities or degradation products using chromatographic and spectral methods)
Assay of drugs (pharmacopoeial methods of quantitative evaluation of drugs)
Control-analytical evaluation of pharmaceutical preparations
Control of extemporaneously prepared pharmaceutical preparations according to pharmacopoeia and analytical procedures used in laboratories of national authorities
Control of mass-manufactured pharmaceutical preparations according to the regulations of producers (control-analytical methods used in release control in pharmaceutical industry)
Work with pharmaceutico-analytical literature
Tasks solved by semi-demonstrational form (UV spectrophotometry use in Pharmaceutical analysis, IR spectrophotometry use in drug control, analysis of drugs on the basis of specific optical rotation, analysis of drugs using HPLC, monitoring of drugs and metabolites in blood plasma using HPLC)