General Pharmacology 2023/2024

week

Teach.Unit No.

LECTURES

Teach.Unit No.

PRACTICALS

1

2/10-6/10

1

Introduction to pharmacology. Principles of pharmacokinetics

J. Slíva

2

Basics of drug prescription. Introduction to pharmacology.

Basic terminology. Organization of teaching and testing.

J. Slíva, P. Potměšil

2

9/10-13/10

3

Biotransformation and elimination of drugs, drug interactions.

J. Slíva

4

QUIZ - Basics of pharmacokinetics

Pharmacokinetics, single and repeated dose administration, changes

in disease states ‒ computer simulations

P. Potměšil

3

16/10-20/10

5

Autonomic pharmacology – parasympathetic system.

M. Lapka

6

QUIZ - Autonomic pharmacology – parasympathetic system.

M agonists, antagonists, Nicot. agonists, antagonists, spasmolytics,

prokinetics, antiglaucomatics, peripheral muscle relaxants.

Case study, drug prescription

M. Šustková

4

23/10-27/10

7

Autonomic pharmacology – sympathetic system.

Ch. Charalambous

8

QUIZ - Autonomic pharmacology – sympathetic system

Alfa/beta agonists, antagonists, catecholamines.

Case study, drug prescription.

P. Potměšil

5

30/10-3/11

9

Drugs acting via dopamine, serotonin,

histamine

M. Šustková

10

1^st TEST for credit – PHARMACOKINETICS (basic principles, biotransformation and elimination of DRUGS, TU drugs TU 1- 4)

QUIZ - Biotransformation and elimination of drugs, drug interactions.

Types of pharmacokinetic drug interactions (level of biotransformation and elimination)

use of MICROMEDEX, AISLP

A. Nazmudtinová

6

6/11-10/11

11

Drugs acting by inhibition of enzymes

J. Slíva

12

QUIZ - Drugs acting via dopamine, serotonin,

histamine

Important drugs acting via dopamine, serotonin, histamine - antipsychotics, antiparkinsonics,

antimigrenics, antiemetics, antihistaminics, H₂-antagonists etc.

Case study, drug prescription

A. Khryaková

7

13/11-17/11

13

Drugs acting via ion channels and

transporters

P. Potměšil

14

2^nd TEST for credit – PHARMACODYNAMICS I (Pharmacology of autonomic nervous system – TU 5, 6, 7, 8)

QUIZ - Drugs acting by inhibition of enzymes

Cholinesterase inhibitors, inhibitors of ACE, cyklooxygenase, HMG-CoA reductase, PDE, etc.

Case study, drug prescription A. Čertilina

8

20/11-24/11

15

Pharmacological options of affecting the essentials regulatory systems - an example of control of blood pressure and systemic circulation

P. Potměšil

16

QUIZ - Drugs acting via ion channels and

transporters

QUIZ - Pharmacological options of affecting the essentials regulatory systems - an example of control of blood pressure and systemic circulation

Examples of drugs acting on ion channels – calcium channel

blockers, local anaesthetics, IPP, antidepressants, etc.

Case study, drug prescription

Treatment of hypertension - case studies, drug prescription

P. Potměšil

9

27/11-1/12

17

Drug and remedy addiction

M. Šustková

18

Phytotherapy

M. Šustková, A. Khryaková

10

4/12-8/12

19

ATMP Drugs. Biologic therapy, gene therapy

J. Slíva

20

3^rd TEST for credit PHARMACODYNAMICS II (pharmacology of selected receptors, ion channels, enzymes and regulatory systems – TU 9, 11-16, 18)

QUIZ - Basic terms in drug and remedy addiction

Alcohol, tobacco and drugs

M. Šustková

11

11/12-15/12

21

Adverse drug reactions. Regulatory agencies (EMA). Pharmacovigilance

Pharmacoeconomics.

M. Votava

22

Pharmacovigilance in common praxis

M. Pohl

12

18/12-22/12

23

Drug discovery and development. Evidence of drug efficacy. EBM. Placebo.

M. Votava

24

QUIZ - Drug discovery and development. Evidence of drug efficac