Lectures:

Lecturer: Prof. Dr. Emil Rudolf, Ph.D.

Cytogenetics – principles, rules, medically relevant cases (aberrations of chromosomes)
The human genome – structure, function and diseases
Single gene inheritance – pedigrees, rules, examples
Multifactorial inheritance – rules, study methods, examples
Sex determination, genetics of sex development in man and DSDs
Pharmacogenetics and immunogenetics – rules, study methods, examples
Molecular genetic techniques in practical and clinical use
Tumor biology – introduction and basic principles

Practical courses:

Lecturers:

Prof. Dr. Emil Rudolf, Ph.D.
Assoc prof. Dr. Vera Kralova, Ph.D.

Cytogenetics, cytogenetic diagnostic methods
Test – lecture Cytogenetics (10 points)
Outline and principles of cytogenetic methodology
Microscopic evaluation of human karyotype mount
Karyotype
Test – progress( theory of Karyotype and methods) (5 points)
Karyotyping of human stabilized cells – laboratory (split study subgroups)
Monogenic inheritance (workshop I)
Test – lecture Single-gene inheritance (10 points)
Pedigree analysis, symbols and rules in select human monogenic traits (physiological and pathological)
Examples of mechanisms of inheritance and expression of monogenic traits in man deviating from Mendel´s rules
Basic molecular biology techniques I
Test – progress (e-course Methods part I) (5 points)
Isolation of DNA from human cells (1st subgroup)
Principles of select molecular biology techniques – e-learning (2nd subgroup)
Basic molecular biology techniques II
Test – progress (e-course Methods part I) (5 points)
Isolation of DNA from human cells (2nd subgroup)
Principles of select molecular biology techniques – e-learning (1st subgroup)
Molecular biology methods in medical diagnostics (workshop II)
Test – progress (e-course Methods part II) (10 points)
Processing and analysis of isolated nucleic acids
Examples of the diagnostic use of molecular methods – interactive workshop
Biological typing in man (workshop III)
Test – progress (previous practical class) (10 points)
Practical examples of the use of molecular methods for identification of people – interactive workshop
Polygenic and multifactorial genetics (workshop IV)
Test – lecture Polygenic and multifactorial inheritance (10 points)
Examples of traits and their inheritance – interactive workshop
Tumor biology
Test – preparatory material for the practical class (5 points)
Select phenotypical and histopathological features of tumor cells in vitro and in vivo – permanent mounts
Sporadic, familial and hereditary tumors – occurrence, differences, diagnostics
Population genetics (workshop V)
Test – lecture Population genetics (5 points)
Introductory concepts - Hardy-Weinberg law – interactive workshop
Summary of genetics course
Questions and Answers