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detoxication
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prof. RNDr. Petr Hodek CSc.
Academic staff at Faculty of Science
4 classes
234 publications
Classes
class
Advanced practical course in biochemistry II
MC250C08 |
Faculty of Science
class
Enzymology
+1
MC250P01 |
Faculty of Science
class
Biochemistry I
MC250P03C |
Faculty of Science
Publications
publication
The Anticancer Drug Ellipticine Induces Cytochromes P450 1A1, 1A2 and 3A, Cytochrome b(5) and NADPH:Cytochrome P450 Oxidoreductase in Rat Liver, Kidney and Lung
2013 |
Faculty of Science
publication
Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver
2011 |
Faculty of Science, First Faculty of Medicine, Faculty of Physical Education and Sport
publication
Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy
2011 |
Faculty of Science
publication
A one-electron oxidation of carcinogenic non-aminoazo dye Sudan I by horseradish peroxidase
2008 |
Faculty of Science, Central Library of Charles University
publication
Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid
2008 |
Faculty of Science
publication
Oxidation of carcinogenic 2-nitroanisole by rat cytochromes P450 ? similarity between human and rat enzymes
2008 |
Faculty of Science
publication
Cytochromes P450 reconstituted with NADPH:P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes
2006 |
Faculty of Science
publication
The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib
2022 |
Faculty of Science
publication
Nanomedicine of tyrosine kinase inhibitors
2021 |
Faculty of Science, Second Faculty of Medicine
publication
Apoferritin/vandetanib association is long-term stable but does not improve pharmacological properties of vandetanib
2021 |
Faculty of Science, Second Faculty of Medicine
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