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target-directed ligands
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PharmDr. Vendula Šepsová Ph.D.
External academic staff at Faculty of Pharmacy in Hradec Králové
29 publications
Publications
publication
Structure-Guided Design of N-Methylpropargylamino- Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease
2023 |
Faculty of Science, Faculty of Pharmacy in Hradec Králové
publication
Huprine Y-Tryptophan heterodimers with potential implication to Alzheimer's disease treatment
2021 |
Faculty of Pharmacy in Hradec Králové, First Faculty of Medicine
publication
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
2019 |
Central Library of Charles University, Faculty of Medicine in Hradec Králové
publication
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease
2018 |
Faculty of Pharmacy in Hradec Králové
publication
Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment
2017 |
Publication without faculty affiliation
publication
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity
2015 |
Publication without faculty affiliation
publication
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
2015 |
Publication without faculty affiliation
publication
Non-covalent acetylcholinesterase inhibitors: In vitro screening and molecular modeling for novel selective insecticides
2022 |
Publication without faculty affiliation
publication
Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimer's drugs dealing with cholinergic, amyloid and mitochondrial systems
2021 |
Central Library of Charles University, Faculty of Medicine in Hradec Králové
publication
Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats
2021 |
Faculty of Medicine in Hradec Králové
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