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acetylcholinesterases
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PharmDr. Lukáš Prchal Ph.D.
Academic staff at Faculty of Pharmacy in Hradec Králové
48 publications
Publications
publication
Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition
2024 |
Faculty of Science, First Faculty of Medicine, Third Faculty of Medicine
publication
Structure-Guided Design of N-Methylpropargylamino- Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease
2023 |
Faculty of Pharmacy in Hradec Králové, Faculty of Science
publication
BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS
2023 |
Publication without faculty affiliation
publication
Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides
2022 |
Publication without faculty affiliation
publication
Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents
2022 |
Publication without faculty affiliation
publication
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-D-Aspartate receptors
2021 |
Faculty of Pharmacy in Hradec Králové, Central Library of Charles University, Faculty of Science
publication
Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-D-Aspartate Receptor Antagonists
2021 |
Faculty of Pharmacy in Hradec Králové, Faculty of Science
publication
7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo
2021 |
Faculty of Pharmacy in Hradec Králové, Central Library of Charles University
publication
Huprine Y-Tryptophan heterodimers with potential implication to Alzheimer's disease treatment
2021 |
Faculty of Pharmacy in Hradec Králové, First Faculty of Medicine
publication
Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study
2021 |
Faculty of Pharmacy in Hradec Králové
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