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c-h activation
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PharmDr. Lukáš Prchal Ph.D.
Academic staff at Faculty of Pharmacy in Hradec Králové
48 publications
Publications
publication
Structure-Guided Design of N-Methylpropargylamino- Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease
2023 |
Faculty of Pharmacy in Hradec Králové, Faculty of Science
publication
2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1
2023 |
Faculty of Pharmacy in Hradec Králové
publication
An efficient synthesis and cytotoxic profile of D-ribo- phytosphingosine and its analogues
2023 |
Publication without faculty affiliation
publication
7-Azaindole, 2,7-diazaindole, and 1H-pyrazole as core structures for novel anticancer agents with potential chemosensitizing properties
2022 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation
2022 |
Faculty of Pharmacy in Hradec Králové
publication
Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides
2022 |
Publication without faculty affiliation
publication
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-D-Aspartate receptors
2021 |
Faculty of Pharmacy in Hradec Králové, Central Library of Charles University, Faculty of Science
publication
Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-D-Aspartate Receptor Antagonists
2021 |
Faculty of Pharmacy in Hradec Králové, Faculty of Science
publication
The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs
2021 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study
2021 |
Faculty of Pharmacy in Hradec Králové
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