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Mgr. Radek Indra Ph.D.
Academic staff at Faculty of Science
3 classes
26 publications
Classes
class
Biochemistry
MC250P03B |
Faculty of Science
class
Molecular oncology
MC250P63 |
Faculty of Science
class
Biochemistry for IES
MO550P88 |
Faculty of Science
Publications
publication
The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib
2022 |
Faculty of Science
publication
Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems
2020 |
Faculty of Science, Second Faculty of Medicine
publication
Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b(5) Activity
2020 |
Faculty of Science
publication
Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation
2019 |
Faculty of Science, Second Faculty of Medicine
publication
Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro
2018 |
Faculty of Science
publication
Cytochrome b(5) plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine
2017 |
Faculty of Science, Second Faculty of Medicine
publication
The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers
2016 |
Faculty of Science
publication
NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1
2016 |
Faculty of Science
publication
NADH:Cytochrome b(5) Reductase and Cytochrome b(5) Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene
2016 |
Faculty of Science
publication
Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study
2013 |
Faculty of Science
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