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TLR4
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PharmDr. Lukáš Hroch Ph.D.
Externí osoba na 1. lékařská fakulta
15 publikací
Publikace
publication
Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro
2018 |
Publikace bez příslušnosti k fakultě
publication
Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation
2023 |
1. lékařská fakulta
publication
Effects of novel 17 beta-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration
2021 |
1. lékařská fakulta
publication
Alzheimerova nemoc
2020 |
Lékařská fakulta v Hradci Králové
publication
Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer's disease treatment
2020 |
Publikace bez příslušnosti k fakultě
publication
Mitochondriální enzym ABAD a jeho role v rozvoji a léčbě Alzheimerovy nemoci
2020 |
Publikace bez příslušnosti k fakultě
publication
Novel benzothiazole-based ureas as 17 beta-HSD10 inhibitors, a potential Alzheimer's disease treatment
2019 |
Publikace bez příslušnosti k fakultě
publication
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders
2018 |
1. lékařská fakulta
publication
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment
2017 |
Publikace bez příslušnosti k fakultě
publication
6-Benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17 beta-HSD10 and potential drugs for Alzheimer's disease treatment: Design, synthesis and in vitro evaluation
2017 |
Publikace bez příslušnosti k fakultě
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