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intracellular signalling pathway
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PharmDr. Lukáš Hroch Ph.D.
Externí osoba na 1. lékařská fakulta
15 publikací
Publikace
publication
Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation
2023 |
1. lékařská fakulta
publication
Effects of novel 17 beta-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration
2021 |
1. lékařská fakulta
publication
Alzheimerova nemoc
2020 |
Lékařská fakulta v Hradci Králové
publication
Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer's disease treatment
2020 |
Publikace bez příslušnosti k fakultě
publication
Mitochondriální enzym ABAD a jeho role v rozvoji a léčbě Alzheimerovy nemoci
2020 |
Publikace bez příslušnosti k fakultě
publication
Novel benzothiazole-based ureas as 17 beta-HSD10 inhibitors, a potential Alzheimer's disease treatment
2019 |
Publikace bez příslušnosti k fakultě
publication
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders
2018 |
1. lékařská fakulta
publication
Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro
2018 |
Publikace bez příslušnosti k fakultě
publication
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment
2017 |
Publikace bez příslušnosti k fakultě
publication
6-Benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17 beta-HSD10 and potential drugs for Alzheimer's disease treatment: Design, synthesis and in vitro evaluation
2017 |
Publikace bez příslušnosti k fakultě
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