Publications
- Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase II beta Interactions2021 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
- Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite2017 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
- Are cardioprotective effects of NO-releasing drug molsidomine translatable to chronic anthracycline cardiotoxicity settings?2016 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
- Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo2015 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
- In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites2015 | Faculty of Pharmacy in Hradec Králové
- Catalytic Inhibitors of Topoisomerase II Differently Modulate the Toxicity of Anthracyclines in Cardiac and Cancer Cells2013 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
- Methyl and ethyl ketone analogs of salicylaldehyde isonicotinoyl hydrazone: Novel iron chelators with selective antiproliferative action2012 | Faculty of Pharmacy in Hradec Králové
- Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo2021 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
- Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation2021 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
- Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase II beta inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity2021 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
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