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NUCLEAR RECEPTOR
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PharmDr. Tomáš Smutný Ph.D.
Academic staff at Faculty of Pharmacy in Hradec Králové
29 publications
Publications
publication
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure
2023 |
Faculty of Pharmacy in Hradec Králové, First Faculty of Medicine, Central Library of Charles University
publication
Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids
2022 |
Faculty of Pharmacy in Hradec Králové
publication
3 beta-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3 alpha-epimer by hepatic metabolism
2020 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové, Faculty of Science
publication
Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling
2018 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation
2017 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists
2016 |
Faculty of Pharmacy in Hradec Králové
publication
Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation
2016 |
Faculty of Pharmacy in Hradec Králové
publication
Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR)
2015 |
Faculty of Pharmacy in Hradec Králové
publication
Bioinformatic analysis of miRNAs targeting the key nuclear receptors regulating CYP3A4 gene expression: The challenge of the CYP3A4 "missing heritability" enigma
2015 |
Faculty of Pharmacy in Hradec Králové
publication
Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier
2014 |
Faculty of Pharmacy in Hradec Králové
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