Publications
- Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain2020 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové, Faculty of Physical Education and Sport
- Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors2019 | Faculty of Pharmacy in Hradec Králové
- Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation2017 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
- Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation2016 | Faculty of Pharmacy in Hradec Králové
- Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure2023 | Faculty of Pharmacy in Hradec Králové, First Faculty of Medicine, Central Library of Charles University
- Gene Expression Profiling of 1alpha,25(OH)2D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing Genes2022 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Pilsen
- Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids2022 | Faculty of Pharmacy in Hradec Králové
- Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism2021 | Faculty of Pharmacy in Hradec Králové
- 3 beta-Isoobeticholic acid efficiently activates the farnesoid X receptor (FXR) due to its epimerization to 3 alpha-epimer by hepatic metabolism2020 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové, Faculty of Science
- The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids2020 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
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