Publications
- Gene Expression Profiling of 1alpha,25(OH)2D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing Genes2022 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Pilsen
- Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids2022 | Faculty of Pharmacy in Hradec Králové
- The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids2020 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
- Sesquiterpenes Are Agonists of the Pregnane X Receptor but Do Not Induce the Expression of Phase I Drug-Metabolizing Enzymes in the Human Liver2019 | Faculty of Pharmacy in Hradec Králové, Third Faculty of Medicine
- Stilbene compound trans-3,4,5,4'-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver2019 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
- Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors2019 | Faculty of Pharmacy in Hradec Králové
- Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling2018 | Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
- The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator2016 | Faculty of Pharmacy in Hradec Králové
- Laminin-511 and laminin-521-based matrices for efficient hepatic specification of human pluripotent stem cells2016 | Publication without faculty affiliation
- U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells2014 | Faculty of Pharmacy in Hradec Králové
Loading network view...