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Structure-activity relationship (SAR)
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doc. PharmDr. Jaroslav Roh Ph.D.
Academic staff at Faculty of Pharmacy in Hradec Králové
8 classes
65 publications
Classes
class
General and Inorganic Chemistry
+2
GAF124 |
Faculty of Pharmacy in Hradec Králové
class
Diploma Thesis I
GAF163 |
Faculty of Pharmacy in Hradec Králové
class
Exercises in General Chemistry
+1
GB208 |
Faculty of Pharmacy in Hradec Králové
class
Diploma Thesis Elaboration I
GF163 |
Faculty of Pharmacy in Hradec Králové
class
Constitution of Organic Compounds
GF224 |
Faculty of Pharmacy in Hradec Králové
Publications
publication
Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway
2024 |
Faculty of Pharmacy in Hradec Králové
publication
Pyrimidine derivatives with antitubercular activity
2023 |
Faculty of Pharmacy in Hradec Králové
publication
2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1
2023 |
Faculty of Pharmacy in Hradec Králové
publication
The UHPLC-UV method applied for the forced degradation study of ixazomib and HRMS identification of its degradation products
2023 |
Faculty of Pharmacy in Hradec Králové
publication
7-Azaindole, 2,7-diazaindole, and 1H-pyrazole as core structures for novel anticancer agents with potential chemosensitizing properties
2022 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine
2022 |
Faculty of Pharmacy in Hradec Králové
publication
Proline, hydroxyproline, and pyrrolidone carboxylic acid derivatives as highly efficient but reversible transdermal permeation enhancers
2022 |
Faculty of Pharmacy in Hradec Králové
publication
Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase II beta Interactions
2021 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo
2021 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation
2021 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
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