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iron chelators
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doc. PharmDr. Jaroslav Roh Ph.D.
Academic staff at Faculty of Pharmacy in Hradec Králové
8 classes
65 publications
Classes
class
General and Inorganic Chemistry
+2
GAF124 |
Faculty of Pharmacy in Hradec Králové
class
Diploma Thesis I
GAF163 |
Faculty of Pharmacy in Hradec Králové
class
Exercises in General Chemistry
+1
GB208 |
Faculty of Pharmacy in Hradec Králové
class
Diploma Thesis Elaboration I
GF163 |
Faculty of Pharmacy in Hradec Králové
class
Constitution of Organic Compounds
GF224 |
Faculty of Pharmacy in Hradec Králové
Publications
publication
Pharmacokinetics of the cardioprotective drug dexrazoxane and its active metabolite ADR-925 with focus on cardiomyocytes and the heart
2018 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
2,6-Dihydroxybenzaldehyde analogues of the iron chelator salicylaldehyde isonicotinoyl hydrazone: Increased hydrolytic stability and cytoprotective activity against oxidative stress
2018 |
Faculty of Pharmacy in Hradec Králové
publication
Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite
2017 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products
2016 |
Faculty of Pharmacy in Hradec Králové
publication
Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo
2015 |
Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové
publication
In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites
2015 |
Faculty of Pharmacy in Hradec Králové
publication
Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway
2024 |
Faculty of Pharmacy in Hradec Králové
publication
Pyrimidine derivatives with antitubercular activity
2023 |
Faculty of Pharmacy in Hradec Králové
publication
2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1
2023 |
Faculty of Pharmacy in Hradec Králové
publication
The UHPLC-UV method applied for the forced degradation study of ixazomib and HRMS identification of its degradation products
2023 |
Faculty of Pharmacy in Hradec Králové
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