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Multi-target directed ligands
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Dávid Maliňák
External person at Faculty of Pharmacy in Hradec Králové
45 publications
Publications
publication
Donepezil derivatives targeting amyloid-beta cascade in Alzheimer's disease
2019 |
Publication without faculty affiliation
publication
Profiling donepezil template into multipotent hybrids with antioxidant properties
2018 |
Publication without faculty affiliation
publication
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity
2015 |
Publication without faculty affiliation
publication
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
2015 |
Publication without faculty affiliation
publication
Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK)
2023 |
Publication without faculty affiliation
publication
Strategies for enhanced bioavailability of oxime reactivators in the central nervous system
2023 |
Publication without faculty affiliation
publication
BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS
2023 |
Publication without faculty affiliation
publication
Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides
2022 |
Publication without faculty affiliation
publication
Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents
2022 |
Publication without faculty affiliation
publication
Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870
2022 |
Publication without faculty affiliation
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