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p450 reductase
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RNDr. Jitka Poljaková Ph.D.
Academic staff at Faculty of Science
39 publications
Publications
publication
Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2
2008 |
Faculty of Science
publication
Effect of benzo[a]pyrene treatment on hepatic cytochrrome P450 and NADPH: cytochrrome P450 reductase (POR) levels in mice with liver-specific deletion of the POR gene
2007 |
Faculty of Science
publication
Cytochromes P450 reconstituted with NADPH:P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes
2006 |
Faculty of Science
publication
Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells
2015 |
Faculty of Science, Second Faculty of Medicine
publication
Hypoxia-mediated histone acetylation and expression of N-myc transcription factor dictate aggressiveness of neuroblastoma cells
2014 |
Faculty of Science, First Faculty of Medicine, Faculty of Physical Education and Sport, Second Faculty of Medicine
publication
Expression Levels of Enzymes Metabolizing an Anticancer Drug Ellipticine Determined by Electromigration Assays Influence its Cytotoxicity to Cancer Cells - A Comparative Study
2014 |
Faculty of Science, Second Faculty of Medicine
publication
Electrochemical Determination of Enzymes Metabolizing Ellipticine in Thyroid Cancer Cells - a Tool to Explain the Mechanism of Ellipticine Toxicity to these Cells
2013 |
Faculty of Science, Second Faculty of Medicine
publication
Mechanisms of ellipticine-mediated resistance in UKF-NB-4 neuroblastoma cells
2012 |
Faculty of Science, First Faculty of Medicine, Faculty of Physical Education and Sport, Second Faculty of Medicine
publication
Valproic acid overcomes hypoxia-induced resistance to apoptosis
2012 |
Faculty of Science, First Faculty of Medicine, Faculty of Physical Education and Sport, Second Faculty of Medicine
publication
The Synergistic Effects of DNA-Targeted Chemotherapeutics and Histone Deacetylase Inhibitors As Therapeutic Strategies for Cancer Treatment
2012 |
Faculty of Science, First Faculty of Medicine, Faculty of Physical Education and Sport, Second Faculty of Medicine
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