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Molecular modeling
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doc. PharmDr. Jan Korábečný Ph.D.
External academic staff at Faculty of Pharmacy in Hradec Králové
179 publications
Publications
publication
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation
2017 |
Publication without faculty affiliation
publication
Synthesis, antimicrobial evaluation and molecular modeling of 5-hydroxyisoquinolinium salt series; the effect of the hydroxyl moiety
2016 |
Faculty of Pharmacy in Hradec Králové
publication
Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies
2016 |
Publication without faculty affiliation
publication
Preparation of 7-Methoxy Tacrine Dimer Analogs and Their In vitro/In silico Evaluation as Potential Cholinesterase Inhibitors
2015 |
Publication without faculty affiliation
publication
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity
2015 |
Publication without faculty affiliation
publication
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
2015 |
Publication without faculty affiliation
publication
7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies
2014 |
Faculty of Pharmacy in Hradec Králové, Faculty of Science
publication
7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer's Disease Treatment - Synthesis, Biological Evaluation and Molecular Modeling Studies
2013 |
Publication without faculty affiliation
publication
Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine - new tacrine derivate with cholinergic properties
2011 |
Faculty of Physical Education and Sport, First Faculty of Medicine, Faculty of Pharmacy in Hradec Králové
publication
Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition
2024 |
First Faculty of Medicine, Faculty of Science, Third Faculty of Medicine
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