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Multi-target-directed ligands
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RNDr. Jana Janočková Ph.D.
External academic staff at Faculty of Medicine in Hradec Králové
37 publications
Publications
publication
Huprine Y-Tryptophan heterodimers with potential implication to Alzheimer's disease treatment
2021 |
Faculty of Pharmacy in Hradec Králové, First Faculty of Medicine
publication
2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease
2021 |
Publication without faculty affiliation
publication
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
2020 |
Publication without faculty affiliation
publication
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase
2019 |
Publication without faculty affiliation
publication
Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives
2019 |
Publication without faculty affiliation
publication
Profiling donepezil template into multipotent hybrids with antioxidant properties
2018 |
Publication without faculty affiliation
publication
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment
2017 |
Publication without faculty affiliation
publication
Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities
2022 |
Faculty of Medicine in Hradec Králové
publication
Discovery of Dual A beta/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease
2022 |
Publication without faculty affiliation
publication
Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimer's drugs dealing with cholinergic, amyloid and mitochondrial systems
2021 |
Faculty of Medicine in Hradec Králové, Central Library of Charles University
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