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Human cytochromes P450
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RNDr. Dagmar Svášková Ph.D.
Academic staff at Faculty of Science
25 publications
Publications
publication
The anticancer drug ellipticine forms covalent DNA adducts, mediated by human cytochromes P450, through metabolism to 13-hydroxyellipticine and ellipticine N-2-oxide
2004 |
Faculty of Science
publication
Induced Expression of Cytochrome P450 1A and NAD(P)H:Quinone Oxidoreductase Determined at mRNA, Protein, and Enzyme Activity Levels in Rats Exposed to the Carcinogenic Azo Dye 1-Phenylazo-2-naphthol (Sudan I)
2013 |
Faculty of Science
publication
Preparation of a biologically active apo-cytochrome b5 via heterologous expression in Escherichia coli
2009 |
Faculty of Science
publication
Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method
2009 |
Faculty of Science
publication
Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2
2008 |
Faculty of Science
publication
Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice
2008 |
Faculty of Science
publication
DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells
2007 |
Faculty of Science, Second Faculty of Medicine
publication
Formation and persistence of DNA adducts of anticancer drug ellipticine in rats
2007 |
Faculty of Science
publication
Effect of benzo[a]pyrene treatment on hepatic cytochrrome P450 and NADPH: cytochrrome P450 reductase (POR) levels in mice with liver-specific deletion of the POR gene
2007 |
Faculty of Science
publication
The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism
2007 |
Faculty of Science
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