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Structure-activity relationship (SAR)
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PharmDr. Ondřej Benek
External academic staff at First Faculty of Medicine
19 publications
Publications
publication
Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation
2023 |
First Faculty of Medicine
publication
Small-molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria-related diseases
2022 |
Publication without faculty affiliation
publication
Alzheimerova nemoc
2020 |
Faculty of Medicine in Hradec Králové
publication
Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer's disease treatment
2020 |
Publication without faculty affiliation
publication
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
2020 |
Publication without faculty affiliation
publication
Mitochondriální enzym ABAD a jeho role v rozvoji a léčbě Alzheimerovy nemoci
2020 |
Publication without faculty affiliation
publication
Novel benzothiazole-based ureas as 17 beta-HSD10 inhibitors, a potential Alzheimer's disease treatment
2019 |
Publication without faculty affiliation
publication
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders
2018 |
First Faculty of Medicine
publication
Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro
2018 |
Publication without faculty affiliation
publication
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment
2017 |
Publication without faculty affiliation
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