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rational drug design
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Person
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PharmDr. Ondřej Benek
External academic staff at First Faculty of Medicine
19 publications
Publications
publication
Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro
2018 |
Publication without faculty affiliation
publication
Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation
2023 |
First Faculty of Medicine
publication
Small-molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria-related diseases
2022 |
Publication without faculty affiliation
publication
Alzheimerova nemoc
2020 |
Faculty of Medicine in Hradec Králové
publication
Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer's disease treatment
2020 |
Publication without faculty affiliation
publication
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
2020 |
Publication without faculty affiliation
publication
Mitochondriální enzym ABAD a jeho role v rozvoji a léčbě Alzheimerovy nemoci
2020 |
Publication without faculty affiliation
publication
Novel benzothiazole-based ureas as 17 beta-HSD10 inhibitors, a potential Alzheimer's disease treatment
2019 |
Publication without faculty affiliation
publication
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders
2018 |
First Faculty of Medicine
publication
Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment
2017 |
Publication without faculty affiliation
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