Determination of sibiromycin and its natural derivatives using new analytical and structural approaches
2011
Abstract
A new separation and quantification method using ultra high-performance liquid chromatography (UHPLC) with UVdetection was developed for the detection of sibiromycin in fermentation broth of Streptosporangium sibiricum. Also several natural sibiromycin analogues/derivatives were described with pilot characterization using off-line mass spectrometry: the previously described dihydro-sibiromycin (DH-sibiromycin) and tentative bis-glycosyl forms of sibiromycin and its dihydro-analogue.