Time-dependent changes in concentration of two clinically used acetylcholinesterase reactivators (HI-6 and obidoxime) in rat plasma determined by HPLC techniques after in vivo administration
2010
Abstract
A simple and reliable HPLC method for determination of rat plasma levels of clinically used acetylcholinesterase (AChE) reactivators (HI-6 and obidoxime) is presented in our study. HPLC with UV detection presented in our study is a general method which could be applied for quick measurement of bisquaternary AChE reactivators in rat plasma.