Topographical alterations of inner retinal activity during systemic hyperoxia-hypercapnia in normal subjects and patients with type 1 diabetes
Abstract
The purpose of this study was to investigate whether an increase in the circulating oxygen supply can alter inner retinal function, assessed by recordings of multifocal oscillatory potentials. We studied 9 subjects with type 1 diabetes (8 without overt retinopathy, one with 2 microaneurysms) and 10 similar-aged normal subjects.
The central 60 of the retina was stimulated by an array of 61 hexagonal elements, and mfOP recordings were obtained while breathing room air or carbogen. This study demonstrates that some aspects of inner retinal function are modified by the inhalation of carbogen.
The reduced effect of carbogen inhalation on the recordings from the patients with diabetes may be due to compromised vascular perfusion in these subjects.