Effect of atorvastatin on non-cholesterol sterol in patients with type 2 diabetes mellitus and cardiovascular disease
2005
Abstract
An increased risk of cardiovascular morbidity and mortality in diabetes mellitus type 2 has been associated with disturbance of lipid homeostasis. Recently, decreased intestinal absorption of cholesterol and increased liver cholesterol production have~been reported.
We conclude that in spite the total cholesterol level in diabetics type 2 is not increased, its endogenous synthesis is enhanced. Our results show that the diabetics type 2 with increased serum lathosterol and expressed metabolic syndrome~(mild increased of triglycerides) might represent a suitable group for intensive treatment with statins.~