The article presents a brief review of experiences in e-learning used within an international network of cooperating universities with the vision to promote an open European Learning Space and provide a platform for interdisciplinary and intercultural knowledge and experience required to understand sustainability at the European level. Together with a theoretical reflection upon the theme, this analysis should permit generalized and extended usability of the e-learning methodology across diverse contexts of higher education, and potentially include other regional institutions to support the establishment of a regional partnership within Regional Centers of Expertise (RCE).