Dessication of droplets and subsequent formation of "coffee rings" represents very interesting physics in ana ordinary life. In this article, we go further into the region of applications of this phenomenon and we show that it helps to concentrate biomolecules, which are then accessible to Raman spectroscopy.
We address questions about the difference of conformation of biomolecules in "coffee rings" with respect to other phases, finally we give an overview of the present employment of this method as far as biomedical applications.