Investigating Spectrum of Biological Activity of 4- and 5-Chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides

Abstract

A series of twenty-two 5-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides and ten 4-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides is described. The compounds were analyzed using RP-HPLC to determine lipophilicity.

Primary in vitro screening of the synthesized compounds was performed against mycobacterial, bacterial and fungal strains.

Keywords

• salicylanilide derivates
• lipophilicity
• in vitro antimycobacterial activity
• in vitro antifungal activity
• in vitro antibacterial activity
• PET inhibition
• spinach chloroplasts
• structure-activity relationships