Effect of Substitution on the Antimycobacterial Activity of 2-(Substituted benzyl)sulfanyl Benzimidazoles, Benzoxazoles, and Benzothiazoles - A Quantitative Structure-Activity Relationship Study

Abstrakt

A set of the previously published 2-(substituted benzyl)sulfanyl benzimidazoles, benzoxazoles, and benzothiazoles has been analyzed by the methods of multidimensional analysis (exploratory analysis, 2D-nonlinear mapping - NLM, principal component analysis - PCA, factor analysis - FA, multiple linear regression - MLR). The effect of substitution on the antimycobacterial activity has been predicted.

Klíčová slova

• quantitative structure-activity relationship
• benzimidazole
• benzothiazole
• benzoxazole
• 2-benzylsulfanyl derivative
• antimycobacterial activity