Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors - Analogues of SAD-128
2011
Abstract
Nineteen analogues of SAD-128 were prepared and evaluated as cholinesterase inhibitors. The screening results showed promising inhibitory ability of four compounds better to used standards (pralidoxime, obidoxime, BW284c51, ethopropazine, SAD-128).
Four most promising compounds were selected for further molecular docking studies. The SAR was stated from obtained data.
The former receptor studies were reported and discussed.The further in vivo studies were recommended in the view of OP preexposure treatment.