Publikace na Farmaceutická fakulta v Hradci Králové |
2011
Abstrakt
26 flavonoids were analyzed for their iron chelating activity and stability of the formed complexes in four patho/physiologically relevant pH conditions (4.5, 5.5, 6.8, 7.5) and compared with clinically used iron chelator deferoxamine. The study demonstrated that the most effective iron binding site of flavonoids represented 6,7-dihydroxy structure present in baicalein which was not inferior in all tested pH to deferoxamine.