The endocannabinoid system - a Janus-faced modulator of inflammation in the intestinal microcirculation

Abstract

The evidence suggests that release of endocannabinoids and activation of cannabinoid receptors occurs during intestinal inflammation and sepsis and that manipulation of the endocannabinoid system may represent an important therapeutic target in managing sepsis and microcirculatory disturbances. The chapter summarizes current knowledge and suggest future directions in this area of research.

Keywords

• endocannabinoid
• system
• Janus-faced
• modulator
• inflammation
• intestinal
• microcirculation