Electrogastrography in experimental pigs: the influence of gastrointestinal injury induced by dextran sodium sulphate on porcine gastric erythromycin-stimulated myoelectric activity
Abstract
Electrogastrography (EGG) is a non-invasive investigation of gastric myeloelectrical activity. The aim of study was to evaluate the impact of erythromycin on EGG in gastrointestinal toxic injury induced by dextran sodium sulphate (DSS) in experimental pigs.
A total of 84 records were analysed. Baseline dominant frequency of slow waves was fully comparable in both groups.
In Group I, there was a significant increase in dominant frequency after erythromycin administration. There was a flat non-significant and delayed increase in dominant frequency after erythromycin administration in Group II.
The difference between Group I and II at particular time intervals was not significant but a diverse trend was evident. EGG recording enables us to register a gastric myoelectrical effect of prokinetic drugs.
Erythromycin induced a significant increase in the dominant frequency of slow waves. DSS caused toxic injury to the porcine gastrointestinal tract responsable for the delayed and weaker myoelectrical effect of erythromycin in experimental animals.